A case of Crohn's disease combined with inflammatory myofibroblastoma of abdominal wall / 中南大学学报(医学版)

Inflammatory myofibroblastoma (IMT) is a rare solid tumor, and its etiology and pathogenesis are unclear. Crohn's disease is a non-specific intestinal inflammatory disease. The clinical manifestations, laboratory examinations, and imaging examinations of IMT are not specific, making diagnosis difficult. A case of Crohn's disease combined with IMT of abdominal wall was admitted to the Department of Gastroenterology at the Third Xiangya Hospital, Central South University, on Nov. 21, 2017. This patient was admitted to our hospital because of repeated right lower abdominal pain for 4 years. A 6 cm×5 cm mass was palpated in the right lower abdomen. After completing the transanal double-balloon enteroscopy and computed tomographic enterography for the small intestinal, the cause was still unidentified. The patient underwent surgery due to an abdominal wall mass with intestinal fistula on Sept. 12, 2018 and recovered well currently. According to histopathology and immunohistochemistry, he was diagnosed with Crohn's disease combined with IMT. Up to July 2020, the patients still took azathioprine regularly, without abdominal pain, abdominal distension, and other discomfort, and the quality of his life was good.

Tumor miofibroblástico de laringe: reporte de caso clínico y revisión de literatura / Miofibroflástico larynx tumor: case report and literature review

El tumor miofibroblástico inflamatorio de laringe es una patología rara dentro de los tumores de cabeza, cuello y de vía aérea, con una baja prevalencia, existiendo escasa literatura al respecto. Corresponde a un tumor benigno que generalmente se presenta como hallazgo incidental en relación a cuerdas vocales con mayor frecuencia, que puede ser de carácter asintomático o presentarse con clínica de obstrucción de vía aérea como estridor y disnea progresiva, además de disfonía. Puede afectar a pacientes de cualquier edad, siendo más frecuentes en adultos en edad media. El diagnóstico se hace a través de radiología y visualización directa mediante laringoscopía con la consiguiente obtención de muestra y estudio histopatológico. El tratamiento consta en la resección quirúrgica completa de la lesión, asociado o no a terapia esteroidal, sin embargo la curación completa no se logra en todos los casos producto de la naturaleza recidivante de la lesión.

The inflammatory myofibroblastic umor of the larynx is a rare condition in tumors of head, neck and airway, with a low prevalence, and scarce existing literature. It corresponds to a benign tumor that usually occurs as an incidental finding in relation to vocal cords more frequently, which can be asymptomatic or present with clinical character of airway obstruction, as progressive stridor and dyspnea, plus dysphonia. It can affect patients of any age are more common in adults in middle age. The diagnosis is made by radiology and direct laryngoscopy with visualization by obtaining sample and histology. Treatment consists of surgical removal of the entire lesion with or without steroid therapy, however complete healing is not achieved in all the cases product of the recurrent nature of the patology.

The Juscelino Kubitschek government and the Brazilian Malaria Control and Eradication Working Group: collaboration and conflicts in Brazilian and international health agenda, 1958-1961 / O governo JK e o Grupo de Trabalho de Controle e Erradicação da Malária no Brasil: encontros e desencontros nas agendas brasileira e internacional de saúde, 1958-1961

Malaria, a disease which was under control in the beginning of Juscelino Kubitschek government, became the most important endemic disease in 1958, when Brazil made a commitment with the World Health Organization to convert its control programs into eradication programs. For this purpose a Malaria Control and Eradication Group was set up under the leadership of the malaria specialist Mário Pinotti. Malaria would become an important bargaining chip in the context of the development policies of Kubitschek. This article focuses on path of the Malaria Control and Eradication Working Group in Brazil, in its varying relationships with the arguments and guidelines established at international level.

A malária, doença que estava controlada no início do governo de Juscelino Kubitschek, torna-se a mais importante endemia em 1958, quando o Brasil assumiu o compromisso com a Organização Mundial da Saúde de converter seus programas de controle em programas de erradicação. Para isso foi instalado um Grupo de Controle e Erradicação da Malária sob a direção do malariologista Mário Pinotti. A malária seria uma importante moeda de negociação no contexto da política de desenvolvimento de Kubitschek. Este artigo tem como foco a trajetória do Grupo de Trabalho de Controle e Erradicação da Malária no Brasil, em suas diferentes relações com as discussões e normativas travadas e estabelecidas em âmbito internacional.

Mammary-type myofibroblastoma of soft tissue.

A 40-year-old woman presented with a 1 year history of a painless, subcutaneous lump on the right buttock. Clinical examination showed an approximately 6 cm large subcutaneous mass covered by apparently normal-looking skin. No inguinal lymphadenopathy was found. The mass was excised with the clinical diagnosis of fibroma. Histologically, the lesion was consistent with mammary-type myofibroblastoma of soft tissue, a very rare, benign mesenchymal neoplasm with myofibroblastic differentiation. After surgical excision she was free of recurrence over a period of 8 months. This article also challenges the theory that suggests the origin of this tumor to be from the embryonic mammary tissue, adding another case of a site other than the milk lines.

Miofibroblastoma de la mama femenina: reporte de un caso / Miofibroblastoma of the female breast: a case report

El miofibroblastoma constituye una entidad benigna de la mama de presentación muy infrecuente, que afecta principalmente la mama masculina. Su principal característica histológica es su estirpe mesenquimal caracterizada por la proliferación de células fusiformes rodeadas de colágeno y que derivan de los fibroblastos. El tratamiento principal es la cirugía, con tendencia a la preservación de la glándula sobre todo en la mujer. Presentamos el caso de una paciente femenina de 64 años de edad, con un tumor solitario, de crecimiento progresivo durante 5 años, hasta que decide solicitar asistencia médica, planteándose el diagnóstico preoperatorio de una lesión de tipo mesenquimal; la cual posterior al tratamiento quirúrgico y mediante estudios inmunohistoquímicos se confirma la presencia de un miofibroblastoma clásico, siendo estos tumores infrecuentes en la práctica clínica diaria, debiendo ser considerados al momento de hacer diagnóstico diferencial.

The miofibroblastoma is a benign tumor of the breast of very infrequent presentation that mainly affects the male breast. The main histological characteristic is the mesenchymal ancestry characterized by the proliferation of plump and spindle cells surrounded by collagen and that derive from fibroblasts. The surgery is the main treatment with preservation of the breast in female patients. We presented a case of a female patient of 64 years old, which presents a solitary tumor with progressive growth by 5 years, until she decides to ask for medical aid, considering the preoperating diagnosis of an tumor of mesenchymal type; which subsequent to the surgical treatment and confirmed by immunohistochemistry the presence of miofibroblastoma of the breast, being this finding very unusual in the clinical practice, and to be considered at the time of making differential diagnosis.

[Myofibroblastic tumor of the great omuntum]

Myofibroblastic tumors are a spindle cell lesion at indeterminate malignant potential. Abdominal location was rare. We report a case of an unusual location at myofibroblstic tumors in the great omuntum. A 63-year-old women presented with a one year of isolated left hypochondrium pain. Physical examination was normal. CT scan of the abdomen showed a multicystic and a multilocular building-up of the great omentum suggestive of a peritoneal haemolymphangioma. Besides, at the MRI, this lesion showed up with threefold component: cystic, plump and fibrous, all leading towards a myofibroblastic tumor. At laparotomy, there was already a 10 cm diameter cystic tumor of the great omentum, composed of numerous cystic sockets, all filled with a thick brunish substance. A total resection of the great omentum was done, thus taking away the whole tumor. The histological examination confirms the diagnosis of myofibroblastic tumor of great omentum. Post operative evolution was uneventful. One year later there were no signs of recurrence. Myofibroblastic tumors of the great omentum are rare. The diagnosis is often confirmed by careful microscopic examination or immunohistochemical markers. Treatment consists on a complete surgical resection and life time follow-up is needed because the risk of recurrence

Tumores musculares gastrointestinales / Gastrointestinal smooth muscle tumors

Los tumores musculares del tracto gastrointestinal no son frecuentes. Estos tumores pueden afectar desde el esófago hasta el recto, siendo el estómago el que presenta mayor incidencia. Se estudian 19 pacientes con tumores musculares gastrointestinales intervenidos quirúrgicamente en el período 1979-1996; 9 pacientes eran del sexo femenino y 10 del masculino. El promedio de edad al momento del diagnóstico fue de 58,5 años (rango de 37 a 82 años). En 9 casos el tumor estaba localizado en el estómago (47,4 por ciento), 4 en el dudeno (21 por ciento), 4 en el yeyuno (21 por ciento), 1 en el íleon (5,3 por ciento) y 1 en el colon (5,3 por ciento). De estos tumores, el 57,9 por ciento correspondían a leiomiomas y el 41,1 por ciento a leiomiosarcomas. El síntoma más frecuente en los tumores gástricos fue la hemorragia digestiva, en cambio en las lesiones intestinales el síntoma predominante fue el dolor abdominal. Sólo siete pacientes fueron correctamente diagnosticados en el preoperatorio. Se efectó resección quirúrgica del tumor en el 89,5 por ciento de los enfermos. Se analizan el cuadro clínico, hallazgos anatomopatológicos, tratamiento y pronóstico. El tamaño tumoral y la actividad mitótica son los parámetros más importantes como índices pronósticos. La cirugía resectiva del tumor es el único tratamiento efectivo

Hemangioma vegetante intravascular / Vegetating intravascular haemangioma

Comunicamos un caso de Hemangioma Vegetante intravascular (H:V:I:)(Pseudoangiosarcoma de Masson)(P:A:M:) en el musculo de una mujer de 62 años sin lesion vascular prvia(forma primaria),pudiendo obtener la imagen clinica.Volvemos a resaltar el diagnostico diferencial con el angiosarcoma en su aspecto histologico.Preferimos los terminos de H:V:I: o P:A:M: y coincidimos en que la histogenesis corresponde a una forma peculiar de recanalizacion de un trombo (preceso reactivo y no neoplasico).

Estadiamento de Enneking dos tumores músculo-esqueléticos / Enneking staging of musculoskeletal tumors

O autor apresenta a traduçäo e adaptaçäo para a língua portuguesa do estadiamento dos tumores do sistema músculo-esquelético proposto pelo Prof. Willian Enneking e utilizado mundialmente. O autor faz um resumo dos principais tópicos do estadiamento, explicando o texto através de esquemas adaptados das conferências do Prof. Enneking

Lipoma y liposarcoma: estudio clínico patológico y tratamiento quirúrgico y radioterapéutico de tres enfermos de interés / Lipoma and liposarcoma: clinico-pathological study and surgical and radiotherapeutic of 3 patients

Se estudian tres pacientes de interés, dos con liposarcoma y uno con lipomableomórfico de tamaño gigantesco de extremidad inferior. Analizamos la presentación clínica, el estudio patológico, arteriográfico, el tratamiento quirúrgico y de radioterapia y la evolución posterior de los tres pacientes